Faculty Profile
Dr. Varner Judy Varner, Ph.D.
Professor of Medicine in Residence
Office Address:
Division of Hematology-Oncology
University of California
Moores UCSD Cancer Center, MC-0819
3855 Health Sciences Drive
La Jolla, CA 92093-0819
jvarner@ucsd.edu
Office: (858) 822-0086
FAX: (858) 822-1325
| Education/Training | Research Interests | Publications | Laboratory |
Education and Training
| A.B. | Chemistry, Duke University, Durham, NC | 1976-1980 |
| Fulbright Fellowship | University of Basel, Basel, Switzerland | 1980-1981 |
| Ph.D. | University of Basel, Basel, Switzerland | 1981-1988 |
| Postdoctoral fellow | Dept. Molecular Genetics, Tampa Bay Research Institute |
1988-1990 |
| Postdoctoral fellow | Dept. Pharmacology, University of North Carolina, Chapel Hill | 1991-1993 |
Research Interests
Mechanisms regulating tumor angiogenesis, lymphangiogenesis, inflammation and metastasis.
Publications
Avraamides CJ, Garmy-Susini B, Varner JA. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer. 2008 Aug;8(8):604-17.
Garmy-Susini B, Makale M, Fuster M, Varner JA. Methods to study lymphatic vessel integrins. Methods Enzymol. 2007;426:415-38.
Schmid MC, Varner JA. Myeloid cell trafficking and tumor angiogenesis. Cancer Lett. 2007 May 18;250(1):1-8.
Boudreau NJ, Varner JA. The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis. J Biol Chem. 2004 Feb 6;279(6):4862-8.
Zhong J, Eliceiri B, Stupack D, Penta K, Sakamoto G, Quertermous T, Coleman M, Boudreau N, Varner JA. Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1. J Clin Invest. 2003 Jul;112(1):30-41.
Kim S, Bakre M, Yin H, Varner JA. Inhibition of endothelial cell survival and angiogenesis by protein kinase A. J Clin Invest. 2002 Oct;110(7):933-41.
Bakre MM, Zhu Y, Yin H, Burton DW, Terkeltaub R, Deftos LJ, Varner JA. Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor. Nat Med. 2002 Sep;8(9):995-1003.
Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R, Varner JA, Quertermous T. The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation. Microvasc Res. 2002 Jul;64(1):148-61.
Kim S, Harris M, Varner JA. Regulation of integrin alpha vbeta 3-mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A. J Biol Chem. 2000 Oct 27;275(43):33920-8.
Penta K, Varner JA, Liaw L, Hidai C, Schatzman R, Quertermous T. Del1 induces integrin signaling and angiogenesis by ligation of alphaVbeta3. J Biol Chem. 1999 Apr 16;274(16):11101-9.
