Faculty Profile
Dr. Muchmore
Elaine Muchmore, M.D.
Professor of Clinical Medicine
Director, Internal Medicine Residency Training Program
Office Address:
University of California
Internal Medicine Residency Program
200 West Arbor Drive, MC-8425
San Diego, CA 92103
emuchmore@ucsd.edu
Office: (619) 543-3692
FAX: (619) 543-6529
Education and Training
| BS, MA | Biology, Stanford University | 1967-1972 |
| MD | University of California, Davis | 1975-1979 |
| Resident | Virginia Mason Hospital, Seattle | 1979-1982 |
| Fellow | Hematology-Oncology, University of California, San Diego | 1983-1987 |
Research Interests
Dr. Muchmore’s research has been to identify the molecular biological control mechanisms and functional significance involved in regulation of expression of cell surface sialic acid modifications. She has had a specific interest in the regulation of expression of N-glycolylneuraminic (Neu5Gc) acid, an oncofetal antigen that is expressed in normal prenatal human fetus and in some human cancers. Long known as the epitope of serum sickness, Neu5Gc is normally expressed in all subhuman mammals, including chimpanzees. Dr. Muchmore has continued with work to define the specific mutations in a cohort of CHO-K1 mutants that over-express Neu5Gc, anticipating that better understanding of the nuances of the multi-enzyme complex required for Neu5Gc expression will help elucidate regulation of expression in other mammals. The eventual goal is to understand the process by which Neu5Gc is expressed in human cancers, but generally not in normal human tissues, since humans have a nonsense mutation in the gene that converts Neu5Ac to Neu5Gc.
Publications
Muchmore EA, Dahl B. One blue man with mucositis. (1992) NEJM, 327:133.
Hubbard SC, Walls L, Ruley E, Muchmore EA. (1994) Generation of Chinese hamster ovary cell glycosylation mutants by retroviral insertional mutagenesis: integration into a discrete locus generates mutants expressing high levels of N-glycolylneuraminic acid. J Bio Chem 269:3717-24.
Takano R, Mucmore AE, Dennis JW. (1994) Sialylation and malignant potential in tumor cell glycosylation mutants. Glycobiology, 4:665-674.
Muchmore EA, Diaz S, Varki A. (1998) A structural difference between the cell surfaces of humans and the great apes. Am J Phys Anthro 107:187-198.
Chou H-H, Takematsu H, Diaz S, Iber J, Nickerson E, Wright K, Muchmore EA, Nelson DL, Warren ST, Varki A. (1998) A mutation in CMP-sialic acid hydroxylase occurred after divergence of the human lineage from the great apes. Proc Nat Acad Sci, USA,
95:11751-11756.
Muchmore EA. Nonhuman primate models for human disease and immunobiology. (2001). Immunol Rev 83:86-93.
Enard W, Khaitovich P, Close J, Heissig F, Zollner S, Nieselt-Struwe K, Muchmore E, Varki A, Ravid R, Doxiadis GM, Bontrop R, Paabo S. (2001). Intra- and inter-specific variation in primate gene expression patterns. Sciences 296:340-43.
Tangvoranuntakul P, Gagneux P, Diaz S, Varki N, Varki A, Muchmore EA. (2003). Human uptake and incorporation of a non-dietary human sialic acid is associated with xenoreactive and potentially autoreactive antibodies. Proc Nat Acad Sci, USA. 100:12045-50.
Gagneux P, Muchmore EA. (2004). The chimpanzee model: contributions and considerations for study of HBV. In: HBV Protocols, ed. Robert Hamatake and Johnson YN Lau. Humana Press, 289-318.
Muchmore EA. (2005). New ACGME competencies: a training paradigm shift? The Hematologist.
