Faculty Profile
Dr. Helsten Teresa Helsten, M.D.
Assistant Clinical Professor of Medicine
Division of Hematology-Oncology
Office Address:
Division of Hematology-Oncology
University of California, San Diego
Moores UCSD Cancer Center
3855 Health Sciences Drive, MC-0987
La Jolla, CA 92093
thelsten@ucsd.edu
Office: (858) 822-6270
FAX: (858) 822-6196
| Education/Training | Research Interests | Publications | Laboratory |
Education and Training
| BS | Chemistry, Massachusetts Institute of Technology | 1990 |
| MD | University of California, Davis | 1998 |
| Resident | Harbor-UCLA Medical Center | 1998-2001 |
| Chief Resident | Harbor-UCLA Medical Center | 2001-2002 |
Research Interests
Dr. Helsten focuses on providing excellent care for cancer patients, in particular, those with breast cancer. She is one of a core group of multidisciplinary breast cancer providers at the Moores UCSD Cancer Center. As such, she enrolls patients in cooperative group trials as well as industry-sponsored and investigator-initiated clinical trials. She is actively engaged in the design and implementation of translational research projects aimed at studying mechanisms and treatment of bone metastasis in cancer patients. Her current research is focused on DKK1, an inhibitor of the canonical signaling pathway that is important in osteoblast biology, RANK/RANKL signaling inhibition and bone turnover, and the biology of bisphosphonates in cancer patients.
Publications
Helsten TL, Mortimer JE, Corr M. Effective of zoledronic acid on wnt inhibition by dickkopf1 and frizzled-related protein in patients with bone metastases. Breast Cancer Research and Treatment. 2007. 106(Suppl. 1), Abstract #509.
T. Helsten, M. Corr, JE Mortimer. Measurement of DKK1 and FRP in breast and prostate cancer patients with bone metastases: impact of zoledronic acid (ZA). Journal of Clinical Oncology, 2007, ASCO Annual Meeting Proceedings Part I. Vol. 25, No. 18S (June 20 Supplement), 2007: 19659.
Helsten TL, Bunch TA, Kato H, Yamanouchi J, Choi SH, Jannuzi AL, Feral CC, Ginsberg MH, Brower DL, Shattil SJ. Differences in regulation of drosophilia and vertebrate integrin affinity by Talin. Mol Biol Cell. 2008 (19(8):3589.
Bunch TA, Helsten TL, Kendall TL, Shirahatti N, Mahadevan D, Shattil SJ, Brower DL. Amino acid changes in drosophila alphaPS2beta integrins that affect ligand affinity. J Biol Chem. 2006; 281(8):5050-7.
