Faculty Profile
Dr. Adamson
John W. Adamson, M.D.
Professor of Clinical Medicine
Associate Director, Hematology-Oncology
Fellowship Program
Office Address:
Division of Hematology-Oncology
Veterans Administration Medical Center
3350 La Jolla Village Drive, MC-9111E
San Diego, CA 92161jadamson@ucsd.edu
FAX: (858) 552-7485
| Education/Training | Research Interests | Publications | Laboratory |
Education and Training
| BA | University of California, Berkeley | 1958 |
| MD | University of California, Los Angeles | 1962 |
| Internship and Residency | University of Washington | 1962-1964 |
| Fellowship | Senior Fellow in Hematology, University of Washington | 1964-1967 |
Research Interests
Dr. Adamson's long-time interests have been in the regulation of red cell production, and particularly the role of erythropoietin in that process.
He helped organize the original clinical trials of recombinant human erythropoietin in treating the anemia of patients with chronic kidney disease and participated in the application of erythropoietin therapy to the other anemias, including chemotherapy-induced anemia in cancer patients.
He was on the original advisory National Kidney Foundation's Dialysis Outcomes Quality Initiative (DOQI) group that developed guidelines for "best practices" in the use of erythropoietin in kidney-related anemia.
In parallel, he has been invovled in studies of iron metabolism for many years and the role of iron supply to the erythron. He has been particularly interested in the alterations in iron metabolism that occur with acute and chronic inflammation and in the use of supplemental iron to enhance the marrow's response to erythropoietin therapy.
Expanded interests include the mechanisms of anemia as part of the aging process and how to effectively manage the anemia.
Publications
Kochendoerfer, G.G., Chen, S.-Y., Mao, F., Cressman, S., Traviglia, S., Haiyan, S., Hunter, C.L., Low, D.W., Cagle, E.N., Carnevali, M., Gueriguian, V., Keogh, P.J., Porter, H., Stratton, S.M., Wiedeke, M.C., Wilken, J., Tang, J., Levy, J.J., Miranda, L.P., Crnogorac, M.M., Kalbag, S., Botti, P., Schindler-Horvat, J., Savatski, L., Adamson, J.W., Kung, A., Kent, S.B.H, Bradburne, J.A. Design and chemical synthesis of a homogenous polymer-modified erythropoiesis protein. Science 299:884-886, 2003.
Parviz, F., Matullo, C., Garrison, W., Savatski, L., Adamson, J.W., Ning, G., Kaestner, K.H., Rossi, J.M., Zaret, K.S, Duncan, S.A. Hepatocyte nuclear factor 4 alpha controls the development of ahepatic epithelium and liver morphogenesis. Nature Genetics 3493):292-296, 2003.
Collins, A.J. Li, S., Adamson, J.W., Gilbertson, D.T. Assessment of pure red-cell aplasia in US dialysis patients: the limits of the medicare data. American Journal of Kidney Diseases 43(3):464-470, 2004.
von Drygalski, A., Alespeiti, G., Ren, L., Adamson, J.W. Murine bone marrow cells cultured ex vivo in the presence of multiple cytokine combinations loseradioprotectiveand long-term engraftment potential. Stem Cells and Development 24(1):101-111, 2004.
Shander, A., Knight, K., Thurer, R., Adamson, J.W., Spence, R., Prevalence and outcomes of anemia in surgery: A systematic review of the literature. The American Journal ofMedicine 116:58S-69S, 2004.
Adamson, J.W. Iron Deficience and Other hypoproliferative Anemias, in: Harrison's Principles of Internal Medicine, 16th edition. E. Braunwald, A. Fauci, D. Kaster, S. Hauser, D. Longo, J. Jameson, eds. New York, McGraw Hill, 2004, Chapter 90.
Adamson, J.W. and D. Longo, Anemia and Polycythemia, in: Harrison's Principlies of Internal Medicine, 16th edition, E. Braunwald, A. Fauci, D. Kasper, S. Hauser, D. Longo, J. Jameson, eds. New York, McGraw Hill, 2004, Chapter 52.
Chen, S.-Y, Cressman, S., Mao, F., Shao, H., Low, D.W., Beilan, H.S., Cagle, E.N., Carnevalli, M., Gueriguian, V., Keogh, P.J., Porter, H., Stratton, S.M., Wiedeke, M.C.,Savatski, L., Adamson, J.W., Bozzini, C.E., Kung, A., Kent, S.B.H., Bradburne, J.A., Kochendoerfer, G.G. Synthetic erythropoietic proteins turning biologycal performance by site-specific polymer attachment. Chemistry and Biology 12:371-383, 2005.
Hess, J.R., Kagen, L.R., van der Meer, P.F., Simon, T., Cardigan, R., Greenwalt, T.J., AuBuchon, J.P., Brand, A., Lockwood, W., anella, A., Adamson, J., Snyder, E., Taylof, H.L., Moroff, G., Hogman, C. Inter-laboratory comparison of measuring red cellATP, DPG, and haemolysis. Vox Sanguinis 89:44-48, 2005.
von Drygalski, A., Savatski, L., Eastwood, D., Klein, J., Adamson, J.W. The rate of marrow recovery and extent of donor engraftment following transplantation of ex vivo-expanded bone marrow cells are independently influenced by the cytokines used for expansion. Stem Cells and Development 14:564-575, 2005.
Dai, Z., Chen, Y., Schuman, J., Hua, Z., Adamson, J.W., Wen, R., Wang, D. Distinct roles of phosphoinositide-3 kinase and phospholipase C 2 in B-cell receptor-mediated signal transduction. Mol Cell Biol 26:88-99, 2006.
Adamson, J.W. New blood, old blood, or no blood? NEJM 358:12-13, 2008 (Editorial).
AuBuchon, J.P., Dumont, L.J., Herschel, L., Roger, J., Beddard, R.L., Taylor, H.L., Whitley, P.H., Sawyer, S.L., Graminske, S., Martinson, K., Dora, R., Heldke, S., Adamson, J.W., Rose L. Automated collection of double red blood cell units with a variable-volume separation chamber. Transfusion 48:147-152, 2008.
McCullough, J., Kahn, J., Adamson, J.W., Anderlini, P., Confer, D., Benjamin, R., Eapen, M., Hirsch, B., Kuter, D., Lazarus, E., Pamphilon, D., Stroncek, D., Sugarman, J., Wilson R. Hematopoietic growth factors - use in normal blood and stem cell donors: clinical and ethical issues, Transfusion 2008 (in press).
Adamson J.W. Renal disease and anemia in the elderly. Sem Hematol 2008 (in press).
