John W. Adamson, M.D.
Clinical Professor of Medicine
Associate Director, Hematology-Oncology
Division of Hematology-Oncology
Veterans Administration Medical Center
3350 La Jolla Village Drive, MC-9111E
San Diego, CA 92161
FAX: (858) 552-7485
|BA||University of California, Berkeley||1958|
|MD||University of California, Los Angeles||1962|
|Internship and Residency||University of Washington||1962-1964|
|Fellowship||Senior Fellow in Hematology, University of Washington||1964-1967|
Dr. Adamson's long-time interests have been in the regulation of red cell production, and particularly the role of erythropoietin in that process.
He helped organize the original clinical trials of recombinant human erythropoietin in treating the anemia of patients with chronic kidney disease and participated in the application of erythropoietin therapy to the other anemias, including chemotherapy-induced anemia in cancer patients.
He was on the original advisory National Kidney Foundation's Dialysis Outcomes Quality Initiative (DOQI) group that developed guidelines for "best practices" in the use of erythropoietin in kidney-related anemia. "In 2011, he participated in the international effort to harmonize anemia management in patients with CKD as part of the Kidney Disease: Improving Global Outcomes (KDIGO) effort."
In parallel, he has been invovled in studies of iron metabolism for many years and the role of iron supply to the erythron. He has been particularly interested in the alterations in iron metabolism that occur with acute and chronic inflammation and in the use of supplemental iron to enhance the marrow's response to erythropoietin therapy.
Expanded interests include the mechanisms of anemia as part of the aging process and how to effectively manage the anemia.
Adamson, J.W. Iron deficiency and other hypoproliferative anemias. IN: Harrison’s Principles of Internal Medicine, 17th edition. A. Fauci, E. Braunwald, D. Kasper, S. Hauser, D. Longo, J. Jameson, J. Loscalzo, eds. New York, McGraw Hill, 2007, Chapter 98.
Adamson, J.W. and D. Longo. Anemia and polycythemia. IN: Harrison’s Principles of Internal Medicine, 17th edition. A. Fauci, E. Braunwald, D. Kasper, S. Hauser, D. Longo, J. Jameson, J. Loscalzo, eds. New York, McGraw Hill, 2007; Chapter 58.
Adamson, J.W. New blood, old blood, or no blood? NEJM 358:12-13, 2008 (Editorial).
AuBuchon, J.P., Dumont, L.J., Herschel, L., Roger, J., Beddard, R.L., Taylor, H.L., Whitley, P.H., Sawyer, S.L., Graminske, S., Martinson, K., Dora, R., Heldke, S., Adamson, J. and Rose L. Automated collection of double red blood cell units with a variable-volume separation chamber. Transfusion 48:147-152, 2008.
McCullough, J., Kahn, J., Adamson, J., Anderlini, P., Confer, D., Benjamin, R., Eapen, M., Hirsch, B., Kuter, D., Lazarus, E., Pamphilon, D., Stroncek, D., Sugarman, J. and Wilson, R. Hematopoietic growth factors – use in normal blood and stem cell donors: clinical and ethical issues. Summary of a conference. Transfusion 48:2008-2025; 2008.
Adamson, J.W. Renal disease and anemia in the elderly. Semin Hematol 45:235-241, 2008.
Adamson, J.W. Hyporesponsiveness to erythropoiesis stimulating agents in chronic kidney disease: the many faces of inflammation. Adv Chronic Kid Disease 16:76-82, 2009.
Adamson, J.W. Erythropoietic-stimulating agents: the cancer progression controversy and collateral damage to the blood supply. Transfusion 49:824-826; 2009 (Editorial).
Blajchman, M.A., Glynn, S.A., Josephson, C.D. and Kleinman, S.H. for the State-of-the-Science Symposium Transfusion Medicine Committee. J. W. Adamson, contributing author and Co-Chair, Medical and Blood Donor Issues. Transfusion Medicine Reviews 24:259-285; 2010.
Vassallo, R., Adamson, J., Gottschall, J., Snyder, E., Lee, W., Houghton, J. and Elfath, D. In vitro and in vivo evaluation of apheresis platelets stored for 5 days in 65% platelet additive solution/35% plasma. Transfusion 50:2376-2385; 2010. Adamson, J.W.
Iron deficiency and other hypoproliferative anemias. IN: Harrison’s Principles of Internal Medicine, 18th edition. D. Longo, A. Fauci, D. Kasper, S. Hauser, J. Jameson, J. Loscalzo, eds. New York, McGraw Hill, 2011, Chapter 103.
Adamson, J.W. and D. Longo. Anemia and polycythemia. IN: Harrison’s Principles of Internal Medicine, 18th edition. D. Longo, A. Fauci, D. Kasper, S. Hauser, D. Longo, J. Jameson, J. Loscalzo, eds. New York, McGraw Hill, 2011; Chapter 57.
von Drygalski, A. and Adamson, J.W. Ironing out fatigue. Inside Blood (editorial). Blood 118:3191-3192, 2011.
von Drygalski, A. and Adamson, J.W. Iron Metabolism. Review. Journal of Parenteral and Enteral Nutrition. 2012 (in press).
Brugnara, C. and Rifai, N. (Moderators). Adamson, J.W. et al. Experts. Iron deficiency: what are the future trends in diagnostics and therapeutics? Clinical Chemistry. 2012 (in press).